Genes shared with yeast could help humans fight aging
10:18 13 March 2008 by Bob Holmes
Many of the genes that control the lifespan of roundworms serve the same function in yeast, say researchers. This gives a strong hint that mammals, including humans, may manage longevity in a similar way.
If so, identifying these genes should give scientists new leverage in their quest to slow ageing in people and defer the onset of different age-related diseases.
"We spend huge amounts of money on cancer and heart disease that affect a subset of ageing individuals," says Brian Kennedy, an ageing researcher at the University of Washington in Seattle, US. "Targeting ageing directly is an unexplored approach to potential therapies for a whole bunch of these diseases."
For nearly two decades, researchers have known that inactivating specific genes can make roundworms and other organisms live much longer than normal. However, until now, no one has known to what extent ageing is regulated by the same genes in different species.
Shared genes
To find out, a team led by Kennedy and Matt Kaeberlein, also of the University of Washington, assembled a list of all 276 genes in the roundworm Caenorhabditis elegans for which inactivating the gene extended the worm's lifespan.
The team then looked to see how many of these genes they could be found in the genome of the yeast Saccharomyces cerevisiae as well. They discovered the organisms had 76 of these genes in common.
Further experiments revealed that, for 11 of these 76, deleting the gene also made the yeast live longer.
In other words, nearly 15% of the genes had the same effect on longevity in both worms and yeast, meaning that their biological roles must have been conserved through the 1.5 billion years since the two organisms last shared a common evolutionary ancestor.
Worm cousins
Furthermore, if these gene functions are that ancient - and that important - the same genes are also likely to regulate longevity in mammals, which are much more closely related to worms than yeasts.
Many of the shared longevity genes play a role in sensing and responding to nutrient levels in the environment, the researchers found.
This supports the hypothesis that organisms may have evolved genetic mechanisms that mitigate the effects of aging as a response to famine, because this should increase that organism's ability to reproduce. Indeed, caloric restriction - eating barely enough to survive - is one of the few ways to extend the lifespan of almost any organism, from worms to mice and perhaps also people.
Complex mammals
Kennedy's team has begun experiments to test whether the same genes affect longevity in mice. If so, researchers may be able to design drugs to interfere with these genes to help people live longer.
But don't hold your breath, says Kennedy: "It's probably easier to extend lifespan dramatically in a worm or yeast than in a mammal, because the mammals are a more complex organism."
Indeed, some experts are sceptical that caloric restriction, or the gene pathways connected to nutrient sensing, can make much difference at all to human longevity.
Famines rarely last more than a few months or years, so there would be little reason for humans to evolve a genetic mechanism to extend their lifespan any more than that, says Aubrey de Grey, chairman of the Methuselah Foundation, a charity which funds anti-ageing research.
Journal reference: Genome Research (DOI: 10.1101/gr.074724.107)
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Phreaking
Phreaking is a slang term coined to describe the activity of a subculture of people who study, experiment with, or explore telecommunication systems, like equipment and systems connected to public telephone networks. The term "phreak" is derived from the words "phone" and "freak". It may also refer to the use of various audio frequencies to manipulate a phone system. "Phreak", "phreaker", or "phone phreak" are names used for and by individuals who participate in phreaking. Additionally, it is often associated with computer hacking. This is sometimes called the H/P culture (with H standing for Hacking and P standing for Phreaking). information on this site is for educational purposes only! Wyretap Network ©2007 - 2010
Disclaimer: The information on this site is for educational and entertainment purposes only. It is not intended to encourage or teach you to break the law, that's what TV is for, albeit in a very flawed manner. The owner(s) of this website will not be held liable for anything you choose to do with the information contained on this site. If you want to learn how to rape, murder, loot, and commit acts of terror on a monumental scale, well, you won't find it here. Instead, tune-in to your nightly news and take a lesson from your 'elected' 'leaders'.
Disclaimer: The information on this site is for educational and entertainment purposes only. It is not intended to encourage or teach you to break the law, that's what TV is for, albeit in a very flawed manner. The owner(s) of this website will not be held liable for anything you choose to do with the information contained on this site. If you want to learn how to rape, murder, loot, and commit acts of terror on a monumental scale, well, you won't find it here. Instead, tune-in to your nightly news and take a lesson from your 'elected' 'leaders'.
Social engineering techniques and terms
All social engineering techniques are based on specific attributes of human decision-making known as cognitive biases.[1] These biases, sometimes called "bugs in the human hardware," are exploited in various combinations to create attack techniques, some of which are listed here:
Pretexting
Pretexting is the act of creating and using an invented scenario (the pretext) to persuade a targeted victim to release information or perform an action and is typically done over the telephone. It is more than a simple lie as it most often involves some prior research or set up and the use of pieces of known information (e.g. for impersonation: date of birth, Social Security Number, last bill amount) to establish legitimacy in the mind of the target. [2]
This technique is often used to trick a business into disclosing customer information, and is used by private investigators to obtain telephone records, utility records, banking records and other information directly from junior company service representatives. The information can then be used to establish even greater legitimacy under tougher questioning with a manager (e.g., to make account changes, get specific balances, etc).
As most U.S. companies still authenticate a client by asking only for a Social Security Number, date of birth, or mother's maiden name, the method is effective in many situations and will likely continue to be a security problem in the future.
Pretexting can also be used to impersonate co-workers, police, bank, tax authorities, or insurance investigators — or any other individual who could have perceived authority or right-to-know in the mind of the targeted victim. The pretexter must simply prepare answers to questions that might be asked by the victim. In some cases all that is needed is a voice that sounds authoritative, an earnest tone, and an ability to think on one's feet.
Phishing
Main article: Phishing
Phishing is a technique of fraudulently obtaining private information. Typically, the phisher sends an e-mail that appears to come from a legitimate business—a bank, or credit card company—requesting "verification" of information and warning of some dire consequence if it is not provided. The e-mail usually contains a link to a fraudulent web page that seems legitimate—with company logos and content—and has a form requesting everything from a home address to an ATM card's PIN.
For example, 2003 saw the proliferation of a phishing scam in which users received e-mails supposedly from eBay claiming that the user’s account was about to be suspended unless a link provided was clicked to update a credit card (information that the genuine eBay already had). Because it is relatively simple to make a Web site resemble a legitimate organization's site by mimicking the HTML code, the scam counted on people being tricked into thinking they were being contacted by eBay and subsequently, were going to eBay’s site to update their account information. By spamming large groups of people, the “phisher” counted on the e-mail being read by a percentage of people who already had listed credit card numbers with eBay legitimately, who might respond.
IVR or phone phishing
This technique uses a rogue Interactive voice response (IVR) system to recreate a legitimate sounding copy of a bank or other institution's IVR system. The victim is prompted (typically via a phishing e-mail) to call in to the "bank" via a (ideally toll free) number provided in order to "verify" information. A typical system will reject log-ins continually, ensuring the victim enters PINs or passwords multiple times, often disclosing several different passwords. More advanced systems transfer the victim to the attacker posing as a customer service agent for further questioning.
One could even record the typical commands ("Press one to change your password, press two to speak to customer service" ...) and play back the direction manually in real time, giving the appearance of being an IVR without the expense.
The technical name for phone phishing, is vishing.
Baiting
Baiting is like the real-world Trojan Horse that uses physical media and relies on the curiosity or greed of the victim.[3]
In this attack, the attacker leaves a malware infected floppy disk, CD ROM, or USB flash drive in a location sure to be found (bathroom, elevator, sidewalk, parking lot), gives it a legitimate looking and curiosity-piquing label, and simply waits for the victim to use the device.
For example, an attacker might create a disk featuring a corporate logo, readily available off the target's web site, and write "Executive Salary Summary Q2 2009" on the front. The attacker would then leave the disk on the floor of an elevator or somewhere in the lobby of the targeted company. An unknowing employee might find it and subsequently insert the disk into a computer to satisfy their curiosity, or a good samaritan might find it and turn it in to the company.
In either case as a consequence of merely inserting the disk into a computer to see the contents, the user would unknowingly install malware on it, likely giving an attacker unfettered access to the victim's PC and perhaps, the targeted company's internal computer network.
Unless computer controls block the infection, PCs set to "auto-run" inserted media may be compromised as soon as a rogue disk is inserted.
Quid pro quo
Quid pro quo means something for something:
An attacker calls random numbers at a company claiming to be calling back from technical support. Eventually they will hit someone with a legitimate problem, grateful that someone is calling back to help them. The attacker will "help" solve the problem and in the process have the user type commands that give the attacker access or launch malware.
In a 2003 information security survey, 90% of office workers gave researchers what they claimed was their password in answer to a survey question in exchange for a cheap pen.[4] Similar surveys in later years obtained similar results using chocolates and other cheap lures, although they made no attempt to validate the passwords.[5]
Other types
Common confidence tricksters or fraudsters also could be considered "social engineers" in the wider sense, in that they deliberately deceive and manipulate people, exploiting human weaknesses to obtain personal benefit. They may, for example, use social engineering techniques as part of an IT fraud.
The latest type of social engineering techniques include spoofing or hacking IDs of people having popular e-mail IDs such as Yahoo!, GMail, Hotmail, etc. Among the many motivations for deception are:
Phishing credit-card account numbers and their passwords.
Hacking private e-mails and chat histories, and manipulating them by using common editing techniques before using them to extort money and creating distrust among individuals.
Hacking websites of companies or organizations and destroying their reputation.
Pretexting
Pretexting is the act of creating and using an invented scenario (the pretext) to persuade a targeted victim to release information or perform an action and is typically done over the telephone. It is more than a simple lie as it most often involves some prior research or set up and the use of pieces of known information (e.g. for impersonation: date of birth, Social Security Number, last bill amount) to establish legitimacy in the mind of the target. [2]
This technique is often used to trick a business into disclosing customer information, and is used by private investigators to obtain telephone records, utility records, banking records and other information directly from junior company service representatives. The information can then be used to establish even greater legitimacy under tougher questioning with a manager (e.g., to make account changes, get specific balances, etc).
As most U.S. companies still authenticate a client by asking only for a Social Security Number, date of birth, or mother's maiden name, the method is effective in many situations and will likely continue to be a security problem in the future.
Pretexting can also be used to impersonate co-workers, police, bank, tax authorities, or insurance investigators — or any other individual who could have perceived authority or right-to-know in the mind of the targeted victim. The pretexter must simply prepare answers to questions that might be asked by the victim. In some cases all that is needed is a voice that sounds authoritative, an earnest tone, and an ability to think on one's feet.
Phishing
Main article: Phishing
Phishing is a technique of fraudulently obtaining private information. Typically, the phisher sends an e-mail that appears to come from a legitimate business—a bank, or credit card company—requesting "verification" of information and warning of some dire consequence if it is not provided. The e-mail usually contains a link to a fraudulent web page that seems legitimate—with company logos and content—and has a form requesting everything from a home address to an ATM card's PIN.
For example, 2003 saw the proliferation of a phishing scam in which users received e-mails supposedly from eBay claiming that the user’s account was about to be suspended unless a link provided was clicked to update a credit card (information that the genuine eBay already had). Because it is relatively simple to make a Web site resemble a legitimate organization's site by mimicking the HTML code, the scam counted on people being tricked into thinking they were being contacted by eBay and subsequently, were going to eBay’s site to update their account information. By spamming large groups of people, the “phisher” counted on the e-mail being read by a percentage of people who already had listed credit card numbers with eBay legitimately, who might respond.
IVR or phone phishing
This technique uses a rogue Interactive voice response (IVR) system to recreate a legitimate sounding copy of a bank or other institution's IVR system. The victim is prompted (typically via a phishing e-mail) to call in to the "bank" via a (ideally toll free) number provided in order to "verify" information. A typical system will reject log-ins continually, ensuring the victim enters PINs or passwords multiple times, often disclosing several different passwords. More advanced systems transfer the victim to the attacker posing as a customer service agent for further questioning.
One could even record the typical commands ("Press one to change your password, press two to speak to customer service" ...) and play back the direction manually in real time, giving the appearance of being an IVR without the expense.
The technical name for phone phishing, is vishing.
Baiting
Baiting is like the real-world Trojan Horse that uses physical media and relies on the curiosity or greed of the victim.[3]
In this attack, the attacker leaves a malware infected floppy disk, CD ROM, or USB flash drive in a location sure to be found (bathroom, elevator, sidewalk, parking lot), gives it a legitimate looking and curiosity-piquing label, and simply waits for the victim to use the device.
For example, an attacker might create a disk featuring a corporate logo, readily available off the target's web site, and write "Executive Salary Summary Q2 2009" on the front. The attacker would then leave the disk on the floor of an elevator or somewhere in the lobby of the targeted company. An unknowing employee might find it and subsequently insert the disk into a computer to satisfy their curiosity, or a good samaritan might find it and turn it in to the company.
In either case as a consequence of merely inserting the disk into a computer to see the contents, the user would unknowingly install malware on it, likely giving an attacker unfettered access to the victim's PC and perhaps, the targeted company's internal computer network.
Unless computer controls block the infection, PCs set to "auto-run" inserted media may be compromised as soon as a rogue disk is inserted.
Quid pro quo
Quid pro quo means something for something:
An attacker calls random numbers at a company claiming to be calling back from technical support. Eventually they will hit someone with a legitimate problem, grateful that someone is calling back to help them. The attacker will "help" solve the problem and in the process have the user type commands that give the attacker access or launch malware.
In a 2003 information security survey, 90% of office workers gave researchers what they claimed was their password in answer to a survey question in exchange for a cheap pen.[4] Similar surveys in later years obtained similar results using chocolates and other cheap lures, although they made no attempt to validate the passwords.[5]
Other types
Common confidence tricksters or fraudsters also could be considered "social engineers" in the wider sense, in that they deliberately deceive and manipulate people, exploiting human weaknesses to obtain personal benefit. They may, for example, use social engineering techniques as part of an IT fraud.
The latest type of social engineering techniques include spoofing or hacking IDs of people having popular e-mail IDs such as Yahoo!, GMail, Hotmail, etc. Among the many motivations for deception are:
Phishing credit-card account numbers and their passwords.
Hacking private e-mails and chat histories, and manipulating them by using common editing techniques before using them to extort money and creating distrust among individuals.
Hacking websites of companies or organizations and destroying their reputation.
The Real ID Coming Soon!!!
Monday, December 14, 2009
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